全文获取类型
收费全文 | 36749篇 |
免费 | 3240篇 |
国内免费 | 2577篇 |
专业分类
化学 | 19951篇 |
晶体学 | 217篇 |
力学 | 1442篇 |
综合类 | 711篇 |
数学 | 7796篇 |
物理学 | 12449篇 |
出版年
2023年 | 285篇 |
2022年 | 508篇 |
2021年 | 1332篇 |
2020年 | 852篇 |
2019年 | 929篇 |
2018年 | 712篇 |
2017年 | 827篇 |
2016年 | 1062篇 |
2015年 | 1089篇 |
2014年 | 1501篇 |
2013年 | 2555篇 |
2012年 | 1672篇 |
2011年 | 1948篇 |
2010年 | 1790篇 |
2009年 | 2262篇 |
2008年 | 2366篇 |
2007年 | 2531篇 |
2006年 | 2028篇 |
2005年 | 1323篇 |
2004年 | 1241篇 |
2003年 | 1211篇 |
2002年 | 1098篇 |
2001年 | 1079篇 |
2000年 | 749篇 |
1999年 | 668篇 |
1998年 | 607篇 |
1997年 | 509篇 |
1996年 | 542篇 |
1995年 | 491篇 |
1994年 | 484篇 |
1993年 | 500篇 |
1992年 | 496篇 |
1991年 | 347篇 |
1990年 | 278篇 |
1989年 | 234篇 |
1988年 | 269篇 |
1987年 | 216篇 |
1986年 | 217篇 |
1985年 | 333篇 |
1984年 | 265篇 |
1983年 | 149篇 |
1982年 | 306篇 |
1981年 | 480篇 |
1980年 | 432篇 |
1979年 | 472篇 |
1978年 | 377篇 |
1977年 | 282篇 |
1976年 | 241篇 |
1974年 | 77篇 |
1973年 | 152篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
61.
62.
Natalia L. Calvo Sebastian O. SimonettiRubén M. Maggio Teodoro S. Kaufman 《Analytica chimica acta》2015
Exposure of cimetidine (CIM) to dry heat (160–180 °C) afforded, upon cooling, a glassy solid containing new and hitherto unknown products. The kinetics of this process was studied by a second order chemometrics-assisted multi-spectroscopic approach. Proton and carbon-13 nuclear magnetic resonance (NMR), as well as ultraviolet and infrared spectroscopic data were jointly used, whereas multivariate curve resolution with alternating least squares (MCR-ALS) was employed as the chemometrics method to extract process information. It was established that drug degradation follows a first order kinetics. 相似文献
63.
Theoretical investigations on the insertion reaction mechanisms of three- membered-ring silylenoid H2 Si Li F with GeH 3R(R = F, OH, NH2) have been systematically carried out by combined density functional theory(DFT) and ab initio quantum chemical calculations. The geometries of all stationary points for these reactions were optimized using the B3 LYP method and then the QCISD method was used to calculate the single-point energies. The calculated results indicate that, there are one precursor complex(Q), one transition state(TS), and one intermediate(IM) which connect the reactants and the products along the potential energy surface. The insertion reactions of three-membered-ring silylenoid with Ge H3 R proceed in a concerted manner, forming H2RSi-Ge H3 and Li F. The calculated potential energy barriers of the three reactions are 29.17, 30.90, and 54.07 k J/mol, and the reaction energies for the three reactions are –127.05, –116.91, and –103.31 k J/mol, respectively. The insertion reactions in solvents are similar to those in vacuum. Under the same situation, the insertion reactions should occur easily in the following order: GeH 3-F GeH 3-OH GeH 3-NH2. The elucidations of the mechanism of these insertion reactions provided a new mode of silicon-germanium bond formation. 相似文献
64.
65.
Leonor Contreras Ignacio Villarroel Camila Torres Roberto Rozas 《Molecules (Basel, Switzerland)》2021,26(6)
Doxorubicin (DOX), a recognized anticancer drug, forms stable associations with carbon nanotubes (CNTs). CNTs when properly functionalized have the ability to anchor directly in cancerous tumors where the release of the drug occurs thanks to the tumor slightly acidic pH. Herein, we study the armchair and zigzag CNTs with Stone–Wales (SW) defects to rank their ability to encapsulate DOX by determining the DOX-CNT binding free energies using the MM/PBSA and MM/GBSA methods implemented in AMBER16. We investigate also the chiral CNTs with haeckelite defects. Each haeckelite defect consists of a pair of square and octagonal rings. The armchair and zigzag CNT with SW defects and chiral nanotubes with haeckelite defects predict DOX-CNT interactions that depend on the length of the nanotube, the number of present defects and nitrogen doping. Chiral nanotubes having two haeckelite defects reveal a clear dependence on the nitrogen content with DOX-CNT interaction forces decreasing in the order 0N > 4N > 8N. These results contribute to a further understanding of drug-nanotube interactions and to the design of new drug delivery systems based on CNTs. 相似文献
66.
67.
Monica D. Prakash Sarah Fraser Jennifer C. Boer Magdalena Plebanski Barbora de Courten Vasso Apostolopoulos 《Molecules (Basel, Switzerland)》2021,26(6)
Background: Carnosine is a dipeptide molecule (β-alanyl-l-histidine) with anti-inflammatory, antioxidant, anti-glycation, and chelating properties. It is used in exercise physiology as a food supplement to increase performance; however, in vitro evidence suggests that carnosine may exhibit anti-cancer properties. Methods: In this study, we investigated the effect of carnosine on breast, ovarian, colon, and leukemic cancer cell proliferation. We further examined U937 promonocytic, human myeloid leukemia cell phenotype, gene expression, and cytokine secretion to determine if these are linked to carnosine’s anti-proliferative properties. Results: Carnosine (1) inhibits breast, ovarian, colon, and leukemic cancer cell proliferation; (2) upregulates expression of pro-inflammatory molecules; (3) modulates cytokine secretion; and (4) alters U937 differentiation and phenotype. Conclusion: These effects may have implications for a role for carnosine in anti-cancer therapy. 相似文献
68.
碲锰镉(CdMnTe)作为性能优异的室温核辐射探测器材料,可用于环境监测和工业无损检测领域。本文中采用Te溶剂Bridgman法生长In掺杂Cd0.9Mn0.1Te晶体,制备成10 mm×10 mm×2 mm大小的室温单平面探测器,研究了该探测器对241Am@59.5 keV γ射线源的能谱响应。通过表征红外透过率、电阻率以及探测器能谱响应等参数,综合评定了探测器用CdMnTe晶体的质量、电学和探测器性能。结果表明,晶片的红外透过率均在55%以上,最好可达到60%。采用湿法钝化,100 V偏压下的漏电流由钝化前的9.48 nA降为钝化后的7.90 nA,钝化后的电阻率为2.832×1010 Ω·cm。在-400 V反向偏压下,CdMnTe探测器对241Am@59.5 keV γ射线源的能量分辨率在钝化前后分别为13.53%和12.51%,钝化后的电子迁移率寿命积为1.049×10-3 cm2/V。研究了探测器的能量分辨率随电压的变化特性,当偏压≤400 V时,探测器的能量分辨率主要由载流子的收集效率决定,而当偏压>400 V时,能量分辨率由漏电流决定。本文研究结果表明,Te溶剂Bridgman法生长的CdMnTe晶体质量较好,电阻率和电子迁移率寿命积满足探测器制备需求。 相似文献
69.
本文探究了多个影响因素对大豆脲酶诱导碳酸钙沉淀(SICP)的影响,以优选出主要影响因素并提供其最佳范围。首先分析了脲酶浓度和温度对脲酶活性的影响;之后通过正交实验设计,进行25种工况的SICP水溶液实验,研究不同因素组合下Ca2+利用率的变化规律;最后借助扫描电子显微镜观测不同工况下生成碳酸钙的形态。结果表明:低温有利于脲酶的保存及活性发挥,5 ℃时脲酶活性能保持21 d以上;同一温度下,脲酶浓度越大,脲酶初始活性越高,脲酶完全失活所需时间越短。pH值、脲酶与胶结液体积比是影响Ca2+利用率的主要因素。为达到较高的Ca2+利用率,脲酶和胶结液最佳体积比为1,氯化钙与尿素最佳浓度比为1.5,Ca2+最佳浓度为1 mol/L。当脲酶浓度较低时生成的六面体状碳酸钙较多;随着脲酶浓度的增大,所沉淀的碳酸钙向球形转变。大豆中富含的天冬氨酸是控制碳酸钙形态的重要因素。 相似文献
70.
A divergence‐free moving particle semi‐implicit framework has been formulated for modeling of multiple miscible fluids having small density ratios (≤ 1.10) in the presence of free surface. A density‐weighted pressure gradient along with a hybrid free‐surface treatment is specifically adopted to incorporate the effect of marginal density difference through a higher‐order kernel. The hybrid free‐surface treatment reduces error in velocity divergence and resulting spurious velocity fluctuation in the vicinity of free surface for low‐velocity system. Scalar transport equation is resolved to update density associated with the particles at every time step. A total of 9 cases of lock‐exchange flow with different lock positions and density ratios have been utilized to validate the proposed framework. The model performs satisfactorily irrespective of lock positions and low density variations (3%‐9%). 相似文献